Weight Loss & Metabolic Health

Tesofensine

A next-generation metabolic regulator that suppresses appetite, enhances mood, and accelerates fat loss through central neurotransmitter balance.

Doctor-Prescribed

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$530.00 (capsule)

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Suppresses appetite and reduces food cravings

Accelerates fat metabolism and energy expenditure

Enhances mood, focus, and mental drive

Helps preserve lean muscle during weight loss

Complements diet and exercise in metabolic therapy programs

What is Tesofensine?

Tesofensine is a centrally acting triple monoamine reuptake inhibitor (TMRI) originally developed for neurodegenerative conditions like Parkinson’s and Alzheimer’s disease. Later studies revealed its remarkable weight-loss potential, making it one of the most promising neuro-metabolic compounds for appetite regulation and fat reduction. By modulating dopamine, serotonin, and norepinephrine levels in the brain, Tesofensine helps the body achieve satiety, stable mood, and enhanced motivation — key factors in sustainable weight management. At PeptideWebMD, Tesofensine is prescribed under physician supervision, ensuring safe integration with diet, exercise, and other peptide-based weight loss therapies.

Note: This product is not approved by the FDA. It is available only via prescription under the supervision of a licensed healthcare provider.

Science & Mechanism of Action

Tesofensine increases the concentration of dopamine, serotonin, and norepinephrine by blocking their reuptake in the brain. This prolongs their activity at neural synapses, influencing appetite control, energy regulation, and motivation.

Suppresses Appetite

Reduces hunger by activating hypothalamic satiety centers.

Boosts Metabolism

Increases thermogenesis and fat oxidation via norepinephrine activation.

Enhances Mood and Focus

Dopamine and serotonin modulation supports mental clarity and emotional balance.

Preserves Lean Muscle

Encourages fat burning while maintaining muscle mass under caloric restriction.

Benefits & Clinical Applications

Scientifically supported benefits across multiple health concerns

For Weight Loss & Appetite Control

Reduces calorie intake naturally without fatigue or irritability
Enhances satiety signaling to prevent overeating
Shown in studies to achieve up to 10% body weight reduction within 24 weeks

For Mood & Motivation

Supports mental resilience and motivation during caloric deficit
Promotes balanced neurotransmission for emotional stability

For Lifestyle Optimization

Complements exercise and nutritional interventions
Can be combined with peptides like AOD 9604, MOTS-c, or Cagrillintide for synergistic results

Physician-Guided Protocol

Safe, effective dosing under medical supervision

For educational reference only. Actual dosage and cycle are determined during medical consultation

Typical Treatment Protocol

Delivery Method

Oral capsule taken in the morning

Typical Range

0.25–1 mg per day

Duration

Typically 8–12 weeks under physician monitoring

Note: All protocols are prescribed and monitored by licensed physicians. Dosing varies based on individual needs, injury severity, and treatment goals. Do not self-administer without medical guidance.

Safety Profile & Considerations

Transparent information about side effects and contraindications

Common Side Effects

Who Should Avoid

Tesofensine is a neuro-metabolic breakthrough — it addresses both the biological and behavioral aspects of weight management by balancing appetite, motivation, and energy regulation

Dr. Jonathan Hinds, MD, FAAMFM, ABAARM Medical Director, PeptideWebMD

Frequently Asked Questions

Common questions about Tesofensine

How is Tesofensine different from other weight-loss peptides? +

Unlike GLP-1 or AOD peptides that act peripherally, Tesofensine acts directly in the brain, targeting neurotransmitter systems that control appetite and energy.

When do results typically appear? +

Appetite suppression is often noticeable within 3–5 days, with measurable fat loss occurring within 2–3 weeks.

Can it be combined with Semaglutide or AOD 9604? +

Yes. Under medical supervision, Tesofensine may be combined with metabolic peptides for enhanced fat loss and appetite control

Does Tesofensine affect mood? +

Yes — it often improves mood, motivation, and focus by optimizing dopamine and serotonin activity.