Tesofensine

Key Benefits

• Potent Appetite Suppression – Reduces caloric intake by promoting satiety and reducing food cravings.
• Accelerated Fat Loss – Promotes lipolysis and increases metabolic rate without muscle loss.
• Enhanced Energy and Focus – Improves cognitive drive and alertness by increasing brain dopamine and norepinephrine.
• Mood Stabilization – May have positive effects on motivation and mood, particularly in calorie-deficit scenarios.
• Synergistic with Lifestyle Interventions – Can enhance results from diet and exercise in metabolic research.

Mechanism of Action

• Tesofensine inhibits the reuptake of dopamine, serotonin, and norepinephrine, prolonging their action in the synaptic cleft.
• These neurotransmitters act on hypothalamic appetite centers, reducing hunger and increasing satiety.
• The increased dopaminergic activity also improves energy and focus, while norepinephrine may enhance thermogenesis and fat burning.

Dosage Recommendations

• Typical Dosage – Research doses range from 0.25 mg to 1 mg daily, with 0.5 mg being a common effective midpoint in studies.
• Administration – Taken orally, usually once daily in the morning to avoid sleep disruption.
• Cycling – Often used in 8–12 week research cycles with or without breaks, depending on metabolic outcomes.

Research and Studies

• Clinical trials have shown significant weight loss, with participants losing up to 10% of body weight over 24 weeks.
• Compared favorably to other weight-loss medications, including orlistat and sibutramine, with better appetite suppression and mood elevation.
• Investigated for neuroprotective and cognitive benefits due to its origin in neurological research.

Possible Side Effects and Contraindications

• Common Side Effects – Dry mouth, insomnia, increased heart rate, mild anxiety, or restlessness in some research subjects.
• Precautions – Not recommended for individuals with uncontrolled hypertension, arrhythmias, or psychiatric conditions without close supervision.
• Drug Interactions – Avoid combining with other stimulant-based or serotonergic compounds unless under controlled research design.

Storage and Handling Instructions

• Store in a cool, dry place away from direct sunlight.
• Keep Tesofensine capsules or tablets tightly sealed and out of reach of unapproved users.
• No refrigeration required for oral forms.

Frequently Asked Questions (FAQs)

• How does Tesofensine differ from other weight-loss peptides or drugs?

Unlike peptides like AOD 9604 or GLP-1 agonists, Tesofensine acts centrally in the brain to suppress appetite and increase energy via neurotransmitter modulation.

• How quickly are effects seen?

Appetite suppression is often noticed within the first few days. Weight loss results typically follow within 2–3 weeks of consistent use.

• Can Tesofensine be combined with other peptides?

It may be used in research alongside metabolic peptides (e.g., MOTS-c, AOD 9604), though stimulant load should be carefully managed.

Medical Disclaimer
Tesofensine is intended for research and educational purposes only. It is not approved for human consumption or to diagnose, treat, cure, or prevent any disease. Always consult a licensed healthcare provider before beginning any research protocol.