KPV

Key Benefits

• Potent Anti-Inflammatory Effects – Reduces pro-inflammatory cytokines like TNF-α and IL-6.
• Supports Gut Healing – Shown to protect and repair the intestinal lining in models of colitis and leaky gut.
• Immune System Modulation – Regulates immune activity without suppressing essential immune responses.
• Skin Health and Repair – Useful in studies involving eczema, dermatitis, and wound healing.
• Non-Hormonal Action – Does not stimulate melanocortin receptors responsible for pigmentation or hormonal changes.

Mechanism of Action

• KPV modulates the NF-κB and MAPK signaling pathways, which are central to the body’s inflammatory response.
• It decreases inflammatory cytokine expression and reduces immune overactivation in epithelial tissues.
• By interacting with melanocortin receptors selectively, it avoids stimulating pigmentation or cortisol pathways.

Dosage Recommendations

• Typical Dosage – 250–500 mcg daily is commonly used in gut or skin-related research models.
• Administration – Can be applied topically, taken orally, or administered via subcutaneous injection, depending on the application.
• Cycling – Used daily or as needed during inflammatory flare-ups or repair phases in research.

Research and Studies

• Animal studies show KPV reduces intestinal inflammation, improves gut barrier integrity, and accelerates healing.
• Topical use has been shown to improve wound healing and reduce redness, irritation, and inflammation in skin models.
• It’s being explored as a non-toxic, non-immunosuppressive therapy for chronic inflammatory conditions like IBD and psoriasis.

Possible Side Effects and Contraindications

• Common Side Effects – Rare and mild; some subjects report slight redness at topical or injection sites.
• Precautions – While safe in most models, researchers should monitor for hypersensitivity during initial use.
• Drug Interactions – None widely reported; however, combining with other immune- modulating peptides should be done cautiously.

Storage and Handling Instructions

• Store reconstituted KPV in a refrigerator at 2–8°C (36–46°F).
• Lyophilized powder should be kept in a cool, dark, dry location.
• Use sterile technique during reconstitution and handling for maximum stability.

Frequently Asked Questions (FAQs)

• Is KPV the same as α-MSH?

No, KPV is a fragment of α-MSH and does not cause pigmentation or hormone-related effects.

• Can KPV be used with BPC-157?

Yes, they are often combined in gut health and inflammation research for synergistic effects.

• Is KPV useful for topical or internal inflammation?

Both — it is researched for skin applications and gastrointestinal healing due to its anti- inflammatory and reparative actions.

Medical Disclaimer

KPV is intended for research and educational purposes only. It is not approved for human consumption or to diagnose, treat, cure, or prevent any disease. Always consult a licensed healthcare provider before beginning any research protocol.