Foxo4-DRI

Key Benefits

• Senescent Cell Removal – Selectively induces apoptosis in aging or damaged cells, promoting healthier cellular environments.
• Anti-Aging Effects – May support tissue rejuvenation and functional recovery in age- related conditions.
• Improved Organ Function – Shown to enhance liver, kidney, and overall organ performance in aging models.
• Enhanced Tissue Regeneration – Supports cellular turnover and renewal, especially in chronically damaged tissues.
• Supports Longevity Research – Studied for its potential to increase healthspan and delay age-associated decline.

Mechanism of Action

• FOXO4-DRI inhibits the binding of FOXO4 to p53, which prevents senescent cells from avoiding apoptosis.
• This disruption allows the body to clear non-functional, aged cells that accumulate with age and contribute to inflammation and dysfunction.
• The removal of senescent cells allows for regeneration and improved function of surrounding healthy tissue.

Dosage Recommendations

• Typical Dosage – Research protocols commonly use 5–10 mg per injection, repeated 1–3 times per week depending on study design.
• Administration – Typically administered via intraperitoneal or subcutaneous injection in animal studies.
• Cycling – Often used in short, intermittent cycles due to its senolytic action and long- term effects on tissue remodeling.

Research and Studies

• Studies in mice show FOXO4-DRI reduces signs of aging, increases fur density, improves kidney function, and enhances physical performance.
• Senolytic therapies like FOXO4-DRI are being explored for their potential in treating Alzheimer’s, fibrosis, cancer, and other age-related disorders.
• Unlike general apoptosis-inducing agents, FOXO4-DRI selectively targets senescent cells, minimizing collateral damage to healthy tissue.

Possible Side Effects and Contraindications

• Common Side Effects – Temporary fatigue, mild flu-like symptoms, or injection site irritation may occur in some research subjects.
• Precautions – Caution should be exercised in studies involving active infections, cancer, or regenerative therapy without medical oversight.
• Drug Interactions – Should not be combined with other senolytics or apoptosis-inducing agents unless part of a supervised protocol.

Storage and Handling Instructions

• Store reconstituted FOXO4-DRI in a refrigerator at 2–8°C (36–46°F).
• Keep the lyophilized form in a cool, dry, and dark location before mixing.
• Ensure sterile conditions are used when reconstituting and administering the peptide.

Frequently Asked Questions (FAQs)

• Is FOXO4-DRI safe for long-term use?

It’s typically used in short cycles due to its powerful senolytic effects. Long-term use is still under investigation.

• What makes FOXO4-DRI unique among anti-aging peptides?

It directly targets and clears senescent cells, which most peptides do not — offering a regenerative, rather than just supportive, anti-aging effect.

• Can it be stacked with other peptides?

It may be stacked with tissue repair peptides like BPC-157 or TB-500 in research, but timing and cycling must be carefully planned.

Medical Disclaimer

FOXO4-DRI is intended for research and educational purposes only. It is not approved for human consumption or to diagnose, treat, cure, or prevent any disease. Always consult a licensed healthcare provider before beginning any research protocol.