B7-33

Key Benefits

• Anti-Fibrotic Action – Helps reduce fibrotic tissue buildup in organs such as the heart, lungs, liver, and kidneys.
• Cardiovascular Protection – May support heart function and reduce post-injury tissue scarring.
• Organ Healing Support – Encourages tissue remodeling and repair in inflammatory or fibrotic states.
• Low Hormonal Activity – Unlike native relaxin-2, B7-33 is non-reproductive and minimizes hormonal side effects.
• Anti-Inflammatory Effects – May contribute to the downregulation of inflammatory cytokines and immune overactivation.

Mechanism of Action

• B7-33 activates the RXFP1 receptor, a key target of relaxin-2, but in a biased manner to favor antifibrotic signaling.
• It selectively promotes ERK1/2 pathways that are involved in tissue protection and repair, while avoiding cAMP-mediated effects that lead to reproductive hormone stimulation.
• This mechanism allows for tissue-specific benefits, especially in organs affected by chronic inflammation or fibrosis, without systemic endocrine disruption.

Dosage Recommendations

• Typical Dosage – Research dosages vary depending on model, with general ranges between 100–500 mcg per day.
• Administration – Commonly administered via subcutaneous or intraperitoneal injection in animal studies.
• Cycling – Protocols vary based on the duration and severity of fibrosis or inflammation being studied.

Dosage Recommendations

• Typical Dosage – Research dosages vary depending on model, with general ranges between 100–500 mcg per day.
• Administration – Commonly administered via subcutaneous or intraperitoneal injection in animal studies.
• Cycling – Protocols vary based on the duration and severity of fibrosis or inflammation being studied.

Research and Studies

• Animal models have shown that B7-33 can reverse or slow the progression of fibrotic tissue buildup in the lungs, heart, and liver.
• Research suggests B7-33 may provide cardiovascular protection post-injury by promoting collagen remodeling and reducing tissue stiffening.
• Its unique action profile makes it safer for long-term study compared to relaxin-2 due to reduced hormonal side effects.

Possible Side Effects and Contraindications

• Common Side Effects – Minor injection site irritation has been reported in some research models.
• Precautions – Not suitable for individuals with hormone-sensitive conditions without proper supervision.
• Drug Interactions – May interact with medications or peptides affecting the cardiovascular or endocrine system; use cautiously in combined research.

Storage and Handling Instructions

• Store reconstituted B7-33 in a refrigerator at 2–8°C (36–46°F).
• Keep the dry (lyophilized) form in a cool, dry, dark environment to maintain potency.
• Use sterile handling procedures during reconstitution and application.

Frequently Asked Questions (FAQs)

• What is B7-33 mainly used for in research?

Primarily studied for anti-fibrotic, cardioprotective, and organ-repair properties.

• How does it compare to relaxin-2?

B7-33 mimics the antifibrotic and protective effects without the reproductive hormone activation linked to relaxin-2.

• Can B7-33 be used in combination with other healing peptides?

Yes, but stacking should be approached cautiously and ideally under the guidance of a medical or research professional.

Medical Disclaimer

B7-33 is intended for research and educational purposes only. It is not approved for human consumption or to diagnose, treat, cure, or prevent any disease. Always consult a licensed healthcare provider before beginning any research protocol.