Ipamorelin

Key Benefits

• Stimulates Natural GH Secretion – Promotes growth hormone release via ghrelin receptor activation.
• Muscle Growth & Recovery – Supports lean mass development and accelerates post- training repair.
• Fat Loss Support – Enhances lipolysis and improves metabolic efficiency.
• Minimal Side Effects – Does not significantly affect cortisol or prolactin levels.
• Anti-Aging Properties – May improve skin, sleep quality, bone density, and general regenerative capacity.

Mechanism of Action

• Ipamorelin binds to the growth hormone secretagogue receptor (GHS-R1a), mimicking the effects of natural ghrelin.
• It triggers GH release from the anterior pituitary without the hormone-suppressing side effects seen with other GHRPs.
• Unlike GHRP-6 or GHRP-2, it does not cause a strong spike in hunger or alter other hormone levels significantly.

Dosage Recommendations

• Typical Dosage – 100–300 mcg per dose, 1–3 times daily, depending on the research objective.
• Administration – Subcutaneous injection is the most common method.
• Cycling – Commonly used in 8–12 week research cycles with intermittent breaks to maintain receptor sensitivity.

Research and Studies

• Clinical studies show Ipamorelin increases GH levels without impacting ACTH, cortisol, or prolactin, even at higher doses.
• Animal and in vitro models demonstrate improved lean body mass, better recovery, and enhanced bone strength.
• Frequently researched in anti-aging protocols, body recomposition studies, and hormone replacement therapy.

Possible Side Effects and Contraindications

• Common Side Effects – Minor injection site irritation, occasional mild flushing or headache.
• Precautions – Not recommended for individuals with active malignancies or hormone- sensitive conditions without supervision.
• Drug Interactions – Can be stacked with CJC-1295, GHRH analogs, or IGF-1 in research; monitor carefully for overlapping effects.

Storage and Handling Instructions

• Store reconstituted Ipamorelin in a refrigerator at 2–8°C (36–46°F).
• Lyophilized powder should be stored in a cool, dry, and dark place until mixed.
• Use sterile handling practices when reconstituting and administering the peptide.

Frequently Asked Questions (FAQs)

• How is Ipamorelin different from GHRP-6 or GHRP-2?

Ipamorelin is more selective and does not significantly raise hunger, cortisol, or prolactin, making it better tolerated.

• Can it be combined with other peptides?

Yes, it is often paired with CJC-1295 for synergistic GH release in research studies.

• When are effects typically noticed?

Improved sleep and recovery may appear within 1–2 weeks, while body composition improvements take longer with consistent use.

Medical Disclaimer

Ipamorelin is intended for research and educational purposes only. It is not approved for human consumption or to diagnose, treat, cure, or prevent any disease. Always consult a licensed healthcare provider before beginning any research protocol.