Immune Modulation & Gut Health

KPV (Oral)

A clinically researched anti-inflammatory peptide for gut repair, immune balance, and skin healing.

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$255.00 (capsule)

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Reduces systemic and localized inflammation

Supports gut lining repair and intestinal health

Promotes skin regeneration and wound healing

Balances immune function without hormonal effects

Non-suppressive, non-stimulatory, and clinically safe

What is KPV (Oral)?

KPV (Lys-Pro-Val) is a naturally occurring peptide fragment derived from α-MSH (alpha-melanocyte-stimulating hormone) known for its potent anti-inflammatory and immunomodulatory properties. Unlike corticosteroids or systemic immunosuppressants, KPV offers targeted inflammation control — helping the body recover without compromising immune function. It is widely researched for its applications in gut repair, skin healing, autoimmune regulation, and chronic inflammation. At PeptideWebMD, KPV therapy is compounded in U.S.-licensed pharmacies and prescribed under medical guidance to support patients dealing with digestive inflammation, skin disorders, or immune-related conditions.

Note: This product is not approved by the FDA. It is available only via prescription under the supervision of a licensed healthcare provider.

Science & Mechanism of Action

KPV works by interrupting key inflammatory signaling pathways in the body — making it a precision tool for immune regulation and tissue repair. This selective mechanism makes KPV ideal for managing localized or systemic inflammation — from gut health to dermatological repair.

Blocks Inflammatory Pathways

Inhibits NF-κB and MAPK cascades to reduce TNF-α, IL-6, and other pro-inflammatory cytokines.

Protects Gut Barrier

Strengthens epithelial integrity, preventing “leaky gut” and restoring normal mucosal defense.

Promotes Skin Recovery

Stimulates collagen remodeling and reduces redness or irritation in inflamed skin.

Non-Hormonal Action

Acts selectively on melanocortin receptors without affecting pigmentation or cortisol levels.

Benefits & Clinical Applications

Scientifically supported benefits across multiple health concerns

For Gut Health & Digestive Inflammation

Helps repair intestinal lining in leaky gut or colitis models
Reduces oxidative and immune-driven damage in the GI tract
Works synergistically with BPC-157 for gut repair and microbiome support

For Skin & Wound Healing

Calms inflammatory skin responses (eczema, psoriasis, dermatitis)
Accelerates tissue repair and reduces redness or irritation
Supports collagen and epithelial regeneration

For Immune Regulation

Balances immune activation without suppression
Reduces inflammatory flare-ups in autoimmune-prone individuals
Promotes recovery from inflammation-related fatigue

Physician-Guided Protocol

Safe, effective dosing under medical supervision

For informational purposes only. Final dosing is determined during medical consultation.

Typical Treatment Protocol

Delivery Method

Subcutaneous injection, oral capsule, or topical formulation

Typical Range

250–500 mcg daily

Duration

Daily or as needed during inflammatory phases

Note: All protocols are prescribed and monitored by licensed physicians. Dosing varies based on individual needs, injury severity, and treatment goals. Do not self-administer without medical guidance.

Safety Profile & Considerations

Transparent information about side effects and contraindications

Common Side Effects

Occasional mild redness or tingling at topical or injection sites; typically short-lived.

Who Should Avoid

Individuals with known hypersensitivity to peptide compounds should use caution.
KPV is considered non-toxic and non-hormonal, with an excellent safety record in research and clinical use.

KPV represents a new generation of anti-inflammatory therapy — targeted, safe, and non-hormonal. It supports gut integrity, skin health, and immune resilience without the drawbacks of traditional steroids.

Dr. Jonathan Hinds, MD, FAAMFM, ABAARM Medical Director, PeptideWebMD

Frequently Asked Questions

Common questions about KPV (Oral)

Is KPV the same as α-MSH? +

No — KPV is a peptide fragment of α-MSH that delivers the anti-inflammatory benefits without pigmentation or hormonal side effects.

Can KPV be combined with other peptides? +

Yes. It’s frequently paired with BPC-157 for gut repair or LL-37 for immune and wound-healing support.

Is KPV used topically or internally? +

Both. It’s used in topical creams for skin healing and oral or injectable forms for internal inflammation.

Does KPV suppress the immune system? +

No. It modulates immune activity — calming excessive inflammation while maintaining normal immune defense.