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LL-37
Immune Modulation & Gut Health

LL-37

A naturally occurring antimicrobial and immune-modulating peptide that strengthens defense, accelerates healing, and restores balance.

Doctor-Prescribed
Lab-Tested Purity
Ships to Your Door
Satisfaction Guarantee
$150.00 (vial)
Broad-spectrum antimicrobial protection against bacteria, viruses, and fungi
Supports immune regulation and balanced inflammatory response
Accelerates wound and tissue healing
Promotes skin and respiratory health
Doctor-guided therapy, compounded in U.S. licensed pharmacies

What is LL-37?

LL-37 is a naturally produced host defense peptide derived from the body’s innate immune system. It provides broad-spectrum antimicrobial action while also regulating inflammation and tissue repair. Unlike antibiotics, LL-37 does not promote bacterial resistance. Instead, it enhances the body’s natural immune defense, helping to protect against infection while supporting regeneration of damaged tissue. At PeptideWebMD, LL-37 therapy is prescribed by licensed physicians for patients seeking advanced immune resilience, improved healing, and recovery from chronic inflammation or recurrent infections.

Note: This product is not approved by the FDA. It is available only via prescription under the supervision of a licensed healthcare provider.

Science & Mechanism of Action

LL-37 plays a central role in the body’s innate immune system, functioning as both an antimicrobial agent and an immune modulator. This dual antimicrobial and regulatory mechanism makes LL-37 one of the most versatile peptides studied in immune health, tissue regeneration, and chronic infection recovery.

1

Destroys Pathogens

Binds to microbial membranes, forming pores that neutralize bacteria, fungi, and viruses.

2

Modulates Immunity

Regulates cytokine activity, balancing inflammation to avoid over- or under-activation.

3

Accelerates Repair

Promotes migration and proliferation of fibroblasts and keratinocytes, key for wound healing.

4

Enhances Barrier Defense

Strengthens epithelial tissue in skin, gut, and respiratory lining.

Benefits & Clinical Applications

Scientifically supported benefits across multiple health concerns

For Immune Health

  • Strengthens the body’s natural antimicrobial defenses
  • Reduces frequency of recurrent bacterial or viral infections
  • Balances immune response in autoimmune-prone individuals

For Skin & Wound Healing

  • Promotes collagen remodeling and angiogenesis
  • Speeds up healing of ulcers, burns, and chronic wounds
  • Supports skin recovery in eczema and psoriasis

For Respiratory & Gut Support

  • Protects airway epithelium and reduces inflammation in respiratory conditions
  • May support mucosal barrier repair in chronic gut disorders

Physician-Guided Protocol

Safe, effective dosing under medical supervision

For educational reference only. Actual dosing is customized during medical consultation.

Typical Treatment Protocol

Delivery Method
Subcutaneous injection, topical application, or intranasal spray depending on protocol
Typical Range
100–500 mcg per day
Duration
May be used continuously or in treatment cycles targeting immune or wound-healing outcomes

Note: All protocols are prescribed and monitored by licensed physicians. Dosing varies based on individual needs, injury severity, and treatment goals. Do not self-administer without medical guidance.

Safety Profile & Considerations

Transparent information about side effects and contraindications

Common Side Effects

  • Localized redness or mild irritation at the injection or application site; rarely mild fatigue or flushing.

Who Should Avoid

  • Patients with autoimmune disorders or hyper-inflammatory conditions should use LL-37 under close physician supervision to prevent immune overstimulation.
Doctor

LL-37 is a unique peptide that strengthens the body’s innate immune system while supporting natural repair and recovery. It’s one of the few peptides that delivers both antimicrobial protection and healing acceleration.

Dr. Jonathan Hinds, MD, FAAMFM, ABAARM Medical Director, PeptideWebMD

Frequently Asked Questions

Common questions about LL-37

Is LL-37 the same as an antibiotic? +

No. LL-37 is an antimicrobial peptide that disrupts pathogens naturally without contributing to antibiotic resistance.

Can it be used for chronic wounds or skin conditions? +

Yes. LL-37 has shown positive effects on tissue repair, angiogenesis, and re-epithelialization in chronic wound studies.

Does LL-37 boost the immune system? +

It modulates the immune system — enhancing protection while preventing excessive inflammation that can cause tissue damage.

Is LL-37 safe for ongoing use? +

Research suggests a strong safety profile when used under medical supervision, with minimal side effects reported.