Weight Loss & Metabolic Health

MOTS-c

A breakthrough mitochondrial peptide that supports fat metabolism, endurance, and longevity by optimizing cellular energy production.

Doctor-Prescribed

Lab-Tested Purity

Ships to Your Door

Satisfaction Guarantee

$300.00 (vial)

Select Dosage:

Enhances fat oxidation and promotes efficient energy utilization

Improves insulin sensitivity and supports metabolic balance

Boosts endurance and recovery through mitochondrial activation

Supports healthy aging by stimulating AMPK longevity pathways

Doctor-prescribed therapy compounded through licensed U.S. pharmacies

What is MOTS-c?

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a mitochondria-derived peptide that plays a critical role in regulating cellular metabolism, energy balance, and stress adaptation. Unlike most peptides that act on the endocrine system, MOTS-c operates at the mitochondrial level, helping the body optimize fuel utilization and resist metabolic stress. It is currently being researched for its potential to support fat loss, improve insulin function, enhance exercise performance, and slow age-related metabolic decline. At PeptideWebMD, MOTS-c therapy is medically guided to help patients improve energy, endurance, and overall metabolic efficiency.

Note: This product is not approved by the FDA. It is available only via prescription under the supervision of a licensed healthcare provider.

Science & Mechanism of Action

MOTS-c functions as a cellular metabolic regulator, influencing mitochondrial behavior and energy conversion at the genetic level.

Activates AMPK Pathways

Triggers the body’s “energy sensor,” encouraging fat oxidation and glucose uptake.

Enhances Mitochondrial Biogenesis

Supports the creation of new mitochondria for sustained cellular energy.

Balances Metabolic Response

Optimizes energy use during fasting, exercise, and stress conditions.

Benefits & Clinical Applications

Scientifically supported benefits across multiple health concerns

For Weight Management

Promotes fat utilization instead of carbohydrate reliance
Improves body composition and metabolic flexibility
Reduces weight gain under high-fat or high-stress conditions

For Metabolic Health

Enhances insulin sensitivity and glucose uptake
Reduces metabolic fatigue and supports stable blood sugar levels
Protects against age-related metabolic decline

For Performance & Longevity

Boosts stamina and endurance under physical or metabolic stress
Supports mitochondrial health and energy recovery
Activates AMPK for long-term anti-aging and cellular repair benefits

Physician-Guided Protocol

Safe, effective dosing under medical supervision

For educational purposes only. Personalized protocols are prescribed after medical evaluation.

Typical Treatment Protocol

Delivery Method

Subcutaneous injection under clinical supervision

Typical Range

5–10 mg per dose, 2–3 times weekly

Duration

Duration: 4–8 weeks depending on performance and metabolic goals

Note: All protocols are prescribed and monitored by licensed physicians. Dosing varies based on individual needs, injury severity, and treatment goals. Do not self-administer without medical guidance.

Safety Profile & Considerations

Transparent information about side effects and contraindications

Common Side Effects

Occasional fatigue or mild soreness at the injection site; generally well tolerated.

Who Should Avoid

Patients with unmanaged metabolic or endocrine disorders should consult their physician before use.

MOTS-c is one of the most promising mitochondrial peptides for metabolic health. It improves how cells use energy, enhances endurance, and supports longevity — all by working directly at the cellular level.

Dr. Jonathan Hinds, MD, FAAMFM, ABAARM Medical Director, PeptideWebMD

Frequently Asked Questions

Common questions about MOTS-c

Is MOTS-c used for weight loss? +

Yes, it helps optimize fat metabolism and improve body composition by activating AMPK and promoting mitochondrial efficiency.

Does it enhance workout performance? +

Studies show MOTS-c improves endurance, stamina, and recovery by supporting energy output during stress.

Can MOTS-c be combined with other peptides? +

Yes, it’s often stacked with AOD-9604, BPC-157, or Tesamorelin to enhance results, depending on the goal.

Is MOTS-c an anti-aging peptide? +

Yes, research suggests MOTS-c helps regulate mitochondrial function and energy homeostasis — both key to healthy aging.